Selected

The circulating metabolome of human starvation
The human adaptive starvation response allows for survival during long-term caloric deprivation. Whether the physiology of starvation …
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Empirical comparison of reduced representation bisulfite sequencing and Infinium BeadChip reproducibility and coverage of DNA methylation in humans
We empirically examined the strengths and weaknesses of two human genome-wide DNA methylation platforms: rapid multiplexed reduced …
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Specific small-RNA signatures in the amygdala at premotor and motor stages of Parkinson's disease revealed by deep sequencing analysis.
MOTIVATION: Most computational tools for small non-coding RNAs (sRNA) sequencing data analysis focus in microRNAs (miRNAs), overlooking …
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The small RNA content of human sperm reveals pseudogene-derived piRNAs complementary to protein-coding genes.
At the end of mammalian sperm development, sperm cells expel most of their cytoplasm and dispose of the majority of their RNA. Yet, …
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A non-biased framework for the annotation and classification of the non-miRNA small RNA transcriptome.
MOTIVATION: Recent progress in high-throughput sequencing technologies has largely contributed to reveal a highly complex landscape of …
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A myriad of miRNA variants in control and Huntington's disease brain regions detected by massively parallel sequencing
Huntington disease (HD) is a neurodegenerative disorder that predominantly affects neurons of the forebrain. We have applied the …
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SeqBuster, a bioinformatic tool for the processing and analysis of small RNAs datasets, reveals ubiquitous miRNA modifications in human embryonic cells
High-throughput sequencing technologies enable direct approaches to catalog and analyze snapshots of the total small RNA content of …
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